Model, equation, code, and curve—kept in sync
Change one parameter, predict the consequence, then compare the mechanism, formula, implementation, and curve. Values are theoretical teaching examples, not fitted clinical results.
Parameter lab
Predict first:
Equation
Code
Curve
Correct versus misspecified diagnostics
Interpret first: Which panel shows a systematic model failure, what is the likely cause, and what targeted check should come next?
Schematic diagnostic comparison. The time trend suggests missing dynamics or timing problems; first verify time, dose history, and study-specific data, then test a targeted structural remedy.
Dose-regimen simulator
Try this: Keep the daily dose constant—compare 100 mg every 12 h with 200 mg every 24 h. Which regimen produces the smaller peak–trough swing?
What the curve means
NONMEM event encoding
Deterministic one-compartment simulation for education. It demonstrates regimen mechanics and is not a patient-specific dose recommendation.